Media Tablet

Media Tablet

what factors does one need to consider when trying to develop a dissolution medium for a tablet?

I wish to perform dissolution tests on some tablets e.g. Glimepiride tablets, Nevirapine tablets, Lamivudine tablets, Stavudine capsules.I want to know how the choice of dissolution medium is arrived at and what factors contribute to the choice of the medium

aye carrumba, very tricky question here. I'll try to give it a shot.

You'll have to pick a dissolution media AND apparatus that has some sort of correlation to the medium that the tablets will be used in. For instance if the binder is highly water soluble, water may not be the best medium choice since stomach fluid is clearly not pure water.To do this you will need to have some sort of idea how quickly the tablets dissolve in-vivo (is it a quick release, or slow release, does it dissolve on contact, or is there a barrier coat?). From here you should be able to make some medium choices based on similar drugs and especially the binder in the tablet, since that is really what you are trying to dissolve. Next, select an apparatus that should go well with your expected in-vivo dissolution profile.

There is actually a fair amount of trial and error associated with this activity in industry for new drugs/binders/delivery methods. However, if you are working a generic replacement or very similar drug with a well understood binder, previous experience will be a good guide.

In fact you can go to the FDA database for some help with this:

http://www.fda.gov/cder/dmethods/FAQ.htm

They have a database of dissolution methods that may be helpful to narrow down your initial choices.

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